Marvin J Slepian Selected Research

Artificial Heart (Artificial Hearts)

1/2020	Bond Graph Modeling of Mechanical Circulatory Support Device-Cardiovascular System Interactions.
7/2017	A Physical Heart Failure Simulation System Utilizing the Total Artificial Heart and Modified Donovan Mock Circulation.
6/2016	Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner.
5/2015	Physiological characterization of the SynCardia total artificial heart in a mock circulation system.
1/2015	The platelet hammer: In vitro platelet activation under repetitive hypershear.
12/2014	Numerical model of full-cardiac cycle hemodynamics in a total artificial heart and the effect of its size on platelet activation.
1/2014	Numerical model of total artificial heart hemodynamics and the effect of its size on stress accumulation.
5/2008	Risk factor analysis for bridge to transplantation with the CardioWest total artificial heart.
2/2008	The total artificial heart in refractory cardiogenic shock: saving the patient versus saving the heart.
8/2004	Cardiac replacement with a total artificial heart as a bridge to transplantation.

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Marvin J Slepian Research Topics

Disease

19	Heart Failure 01/2020 - 08/2004
15	Thrombosis (Thrombus) 12/2021 - 05/2013
6	COVID-19 01/2022 - 01/2020
4	Critical Illness (Critically Ill) 01/2022 - 07/2004
4	Wounds and Injuries (Trauma) 08/2019 - 09/2002
3	Hemolysis 11/2020 - 07/2016
3	Aortic Valve Stenosis (Aortic Stenosis) 01/2020 - 12/2016
3	Aortic Valve Disease 06/2018 - 02/2013
2	Shock 01/2020 - 01/2020
2	Communicable Diseases (Infectious Diseases) 01/2020 - 01/2020
2	Sepsis (Septicemia) 06/2016 - 05/2008
2	Stroke (Strokes) 12/2015 - 09/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2015 - 12/2011
2	Hemorrhage 05/2014 - 09/2002
2	Coronary Artery Disease (Coronary Atherosclerosis) 09/2013 - 01/2012
2	Acute Coronary Syndrome 09/2013 - 02/2004
2	Inflammation (Inflammations) 12/2011 - 03/2011
1	Proteinuria 10/2021
1	Hematuria 10/2021
1	Pain (Aches) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Coronary Disease (Coronary Heart Disease) 01/2019
1	Hypersensitivity (Allergy) 02/2018
1	Ischemic Stroke 11/2017
1	Ulcer 07/2016
1	Diabetic Foot 07/2016
1	Multiple Organ Failure (MODS) 06/2016
1	Sensorineural Hearing Loss 11/2015
1	Hearing Loss (Hearing Impairment) 11/2015
1	Ototoxicity 11/2015
1	Pulmonary Embolism 09/2013
1	Atrial Fibrillation 09/2013
1	Thromboembolism 09/2013
1	Venous Thrombosis (Deep-Vein Thrombosis) 09/2013
1	Pathologic Constriction (Stenosis) 02/2013
1	Heart Valve Diseases (Valvular Heart Disease) 02/2013
1	Restrictive Cardiomyopathy 01/2013
1	Obesity 01/2012
1	Neoplasms (Cancer) 01/2012
1	Periodontitis 12/2011
1	Periodontal Diseases (Periodontal Disease) 12/2011
1	Chronic Periodontitis 03/2011
1	Cardiogenic Shock 02/2008

Drug/Important Bio-Agent (IBA)

3	Pharmaceutical PreparationsIBA 01/2022 - 11/2015
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 02/2018 - 09/2013
3	Biomarkers (Surrogate Marker)IBA 06/2016 - 03/2011
3	AnticoagulantsIBA 10/2015 - 09/2013
2	Thrombin FDA Link 01/2021 - 02/2018
2	Hemoglobins (Hemoglobin)IBA 11/2020 - 11/2017
2	CytokinesIBA 01/2019 - 12/2011
2	Doxycycline (Periostat)FDA LinkGeneric 12/2011 - 03/2011
1	LipidsIBA 12/2021
1	ApolipoproteinsIBA 10/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2021
1	von Willebrand FactorIBA 11/2020
1	ElementsIBA 08/2019
1	Biological ProductsIBA 01/2019
1	Clopidogrel (Plavix)FDA Link 02/2018
1	TicagrelorIBA 02/2018
1	Sildenafil Citrate (Viagra)FDA Link 11/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2017
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2016
1	4-methyl-2,3-secocholestane-2,3-diolIBA 06/2016
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2016
1	Cisplatin (Platino)FDA LinkGeneric 11/2015
1	GelatinIBA 01/2015
1	Polystyrenes (Polystyrene)IBA 01/2015
1	Dabigatran FDA Link 09/2013
1	AntithrombinsIBA 09/2013
1	Warfarin (Coumadin)FDA LinkGeneric 09/2013
1	PolymersIBA 05/2013
1	pyrolytic carbonIBA 02/2013
1	NF-kappa B (NF-kB)IBA 01/2012
1	C-Reactive ProteinIBA 12/2011
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2011
1	TetracyclinesIBA 12/2011
1	Interleukin-6 (Interleukin 6)IBA 12/2011
1	HDL CholesterolIBA 12/2011
1	CholesterolIBA 12/2011
1	EndotoxinsIBA 12/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 12/2011
1	oxidized low density lipoproteinIBA 12/2011
1	TabletsIBA 03/2011

Therapy/Procedure

22	Therapeutics 01/2021 - 02/2004
19	Heart-Assist Devices 01/2020 - 05/2008
10	Artificial Heart (Artificial Hearts) 01/2020 - 08/2004
5	Extracorporeal Membrane Oxygenation 01/2022 - 01/2020
4	Transcatheter Aortic Valve Replacement 01/2020 - 12/2016
3	Transplantation 01/2020 - 07/2004
3	Surgical Instruments (Clip) 12/2016 - 05/2013
2	Heart Transplantation (Grafting, Heart) 01/2020 - 08/2004
2	Blood Vessel Prosthesis 01/2019 - 11/2015
1	Phototherapy (Light Therapy) 01/2021
1	Low-Level Light Therapy (LLLT) 01/2021
1	Traction 08/2019
1	Sternotomy 11/2015
1	Resuscitation 06/2014
1	Stents 06/2014
1	Mechanical Ventilators (Ventilator) 05/2008